Dead Space walkthrough Chapter 5: Lethal Devotion

Our Dead Space walkthrough shows you how to complete Chapter 5: Lethal Devotion

Guide by Hayden Hefford Former Guides Writer

Updated on Feb. 7, 2023

Looking for a Dead Space remake walkthrough? We’re moving onto Chapter 5: Lethal Devotion in our Dead Space remake walkthrough! This section heads back to Medical, where a mysterious broadcast of Dr. Nicole Brennan is being recorded live. However, things quickly get out of hand, and Isaac ends up facing a new enemy.

In this section of our Dead Space remake walkthrough, we'll guide you through Chapter 5: Lethal Devotion, helping you find any Power Nodes, Text and Audio Logs, and Security Clearance doors while completing the main quest.

You can navigate this Dead Space walkthrough using the pages below:

Dead Space walkthrough Chapter 5: Lethal Devotion

Upon arriving back at Medical, head to the Security Station. When you enter, the doors will mysteriously seal, before a new voice speaks over the radio. Listen to the doctor, and then head into Imaging Diagnostics. Things will look a little different since you last explored here, as the doctor has multiple patients on medical beds. The Necromorph growth has also worsened throughout the Medical bay.

Continue through the corridor and take the cargo lift to the upper level. Head past the Observation Room and through the door that leads to Zero-G Therapy, and then turn right to find Cryogenics. That's where you need to head next, but continue through the next Zero-G door first to find a Security Clearance door that you can now open. Inside, you'll find the Line Racks Schematic and a Power Node.

Head into Cryogenics and take the cargo lift down, opening the nearby container to find another Power Node. Then, turn right in the corridor and smash the fuse to open a shortcut back to Imaging Diagnostics, before heading into the Chemical Lab. Inside, you'll find a hologram of Nicole, so deactivate the fake transmission. This will cause a cutscene in which Dr. Mercer enters and gives you a good ol' villainous monologue.

Dead Space image showing Isaac stumbling to the side as a large red Necromorph bursts from a cage behind him.

How to escape the Hunter and get the Line Gun

When the monologue ends, get ready to run! A red Necromorph Hunter will burst out of a containment tube, and it can't die! Any limbs shot off quickly grow back, so the only solution is to hit it with a Stasis blast and get a headstart. Sprint back to the Security Station to temporarily escape the beast.

You now need to head into the Clinic, where the Hunter will reappear with some other regular necromorph buds. Kill as many as you can, and then use a Stasis blast to slow the Hunter again. This should buy you time to insert the power core back into the nearby wall socket, allowing you to re-enter Hallway A. Within, you'll find a Security Clearance door that you can now enter, where you'll find another Dead Space remake weapon, called the Line Gun. You'll also find a Power Node in a container, and an Audio Log on the desk opposite as you leave.

Dead Space image showing Isaac looking at a Line Gun.

How to lift the lockdown and clear the gas

Leave the Security Clearance room and continue into Hallway B, where you'll need to fight more necromorphs. Then, head through the ICU and into Mercer's office, where you can lift the lockdown. There's also a Text Log on the desk near the necromorph moth corpse.

After lifting the lockdown, leave the office and get ready to run. Mercer will flood the Ishimura with poisonous gas, forcing Isaac to use his Oxygen supplies. Without upgrades, you'll last about 70 seconds, and you need to make it back to the Security Station. Sprint through without stopping to fight any enemies, and head towards the desk in the office to use a terminal that clears the gas.

How to kill the Hunter and get Liquid Nitrogen

After a brief chat with Daniels, you must head back to where you first encountered the Hunter (through Imaging Diagnostics) and into the Cryogenics Lab. The Liquid Nitrogen is simply sat on the floor in the centre of the room, so grab it. Surprise! Of course this was a trap. Mercer appears in a small office on the far side of the room to deliver yet another villainous monologue, so wait for this conversation to end. When it does, the Hunter will burst into the Cryogenics Lab.

Dead Space image showing Isaac aiming at the Hunter inside of a cryogenic lab container.

To kill the Hunter in the Dead Space remake, you must get them to walk through the centre dome where you found the Liquid Nitrogen. Then, hit them with a Stasis blast and run over to the office where Mercer previously gave his monologue. Inside, you can interact with a terminal to lock the Hunter in that centre chamber and freeze them to death. It's hard to get the timing right, but give it a few tries and eventually you should be able to make it in time.

When the Hunter is dead, head into their killbox to grab a Tissue Sample. This will also complete Chapter 5: Lethal Devotion.

For help with Chapter 6: Environmental Hazard, continue onto the next page of our Dead Space remake walkthrough.